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Laminin-modulierte Entzündungsreaktionen in synovialen Fibroblasten von Rheumapatienten


Aicher, W K; Pap, T; Gay, S (2008). Laminin-modulierte Entzündungsreaktionen in synovialen Fibroblasten von Rheumapatienten. Zeitschrift für Rheumatologie, 67(1):59-61.

Abstract

Elevated expression of matrix-metalloproteinases (MMP) contributes to cartilage destruction in rheumatoid arthritis. We report on a novel pathway of inflammatory activation of synovial fibroblasts that is induced by TGF-beta and laminin (extracellular matrix) and leads to increased expression of the proteases MMP-3 and MMP-10. Neither costimulation by the central inflammatory cytokines TNF-alpha and IL-1beta nor NFkB signalling is needed for this pathway.

Abstract

Elevated expression of matrix-metalloproteinases (MMP) contributes to cartilage destruction in rheumatoid arthritis. We report on a novel pathway of inflammatory activation of synovial fibroblasts that is induced by TGF-beta and laminin (extracellular matrix) and leads to increased expression of the proteases MMP-3 and MMP-10. Neither costimulation by the central inflammatory cytokines TNF-alpha and IL-1beta nor NFkB signalling is needed for this pathway.

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Additional indexing

Other titles:Laminin-dependent inflammatory response in synovial fibroblasts of rheumatoid arthritis patients
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:2008
Deposited On:05 Aug 2008 09:10
Last Modified:05 Apr 2016 12:25
Publisher:Springer
ISSN:0340-1855
Publisher DOI:https://doi.org/10.1007/s00393-008-0261-1
PubMed ID:18214499

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