Header

UZH-Logo

Maintenance Infos

Junctional gating: the achilles' heel of epithelial cells in pathogen infection.


Greber, U F; Gastaldelli, M (2007). Junctional gating: the achilles' heel of epithelial cells in pathogen infection. Cell Host & Microbe, 2(3):143-146.

Abstract

Mucosal epithelial cells are a major barrier restricting pathogen entry and, paradoxically, an important entry port for respiratory and enteric viruses. Elegant studies in this issue of Cell Host & Microbe describe how coxsackievirus B3 (related to human poliovirus) infects polarized epithelial cells by engaging two transmembrane proteins of the tight junctions, occludin and CAR. A distinctive endocytic mechanism opens the junctions and gates infectious virus entry.

Abstract

Mucosal epithelial cells are a major barrier restricting pathogen entry and, paradoxically, an important entry port for respiratory and enteric viruses. Elegant studies in this issue of Cell Host & Microbe describe how coxsackievirus B3 (related to human poliovirus) infects polarized epithelial cells by engaging two transmembrane proteins of the tight junctions, occludin and CAR. A distinctive endocytic mechanism opens the junctions and gates infectious virus entry.

Statistics

Citations

16 citations in Web of Science®
14 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

92 downloads since deposited on 11 Feb 2008
23 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:13 September 2007
Deposited On:11 Feb 2008 12:14
Last Modified:21 Nov 2017 13:21
Publisher:Elsevier
ISSN:1931-3128
Publisher DOI:https://doi.org/10.1016/j.chom.2007.08.004
PubMed ID:18005729

Download

Download PDF  'Junctional gating: the achilles' heel of epithelial cells in pathogen infection.'.
Preview
Content: Accepted Version
Filetype: PDF
Size: 179kB
View at publisher