Header

UZH-Logo

Maintenance Infos

New horizons at the caudal embryos: coordinated urogenital/reproductive organ formation by growth factor signaling


Suzuki, K; Economides, A; Yanagita, M; Graf, D; Yamada, G (2009). New horizons at the caudal embryos: coordinated urogenital/reproductive organ formation by growth factor signaling. Current Opinion in Genetics & Development, 19(5):491-496.

Abstract

The cloaca/urogenital sinus and its adjacent region differentiate into the urogenital/reproductive organs. Caudal regression syndrome (CRS; including mermaid syndrome), a type of severe cloacal malformation displays hindlimb fusion and urogenital organ defects, thus suggesting that such defects are caused by several morphogenetic alterations during early development. The attenuation of bone morphogenetic protein (Bmp) signaling at the posterior primitive streak of embryos leads to the caudal dysmorphogenesis including the cloaca and fusion of both hindlimbs. Genetic tissue lineage studies indicate the presence of coordinated organogenesis. Hedgehog (HH)-responding cells derived from peri-cloacal mesenchyme (PCM) contribute to the urogenital/reproductive organs. These findings indicate the existence of developmental programs for the coordinated organogenesis of urogenital/reproductive tissues based on growth factor function and crosstalk.

Abstract

The cloaca/urogenital sinus and its adjacent region differentiate into the urogenital/reproductive organs. Caudal regression syndrome (CRS; including mermaid syndrome), a type of severe cloacal malformation displays hindlimb fusion and urogenital organ defects, thus suggesting that such defects are caused by several morphogenetic alterations during early development. The attenuation of bone morphogenetic protein (Bmp) signaling at the posterior primitive streak of embryos leads to the caudal dysmorphogenesis including the cloaca and fusion of both hindlimbs. Genetic tissue lineage studies indicate the presence of coordinated organogenesis. Hedgehog (HH)-responding cells derived from peri-cloacal mesenchyme (PCM) contribute to the urogenital/reproductive organs. These findings indicate the existence of developmental programs for the coordinated organogenesis of urogenital/reproductive tissues based on growth factor function and crosstalk.

Statistics

Citations

14 citations in Web of Science®
20 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

90 downloads since deposited on 10 Feb 2010
16 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Institute of Oral Biology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:October 2009
Deposited On:10 Feb 2010 15:21
Last Modified:05 Apr 2016 13:52
Publisher:Elsevier
ISSN:0959-437X
Publisher DOI:https://doi.org/10.1016/j.gde.2009.08.004
PubMed ID:19765973

Download