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Targeting apoptosis defects in cutaneous T-cell lymphoma


Contassot, E; French, L E (2009). Targeting apoptosis defects in cutaneous T-cell lymphoma. Journal of Investigative Dermatology, 129(5):1059-1061.

Abstract

Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin's lymphomas characterized by the clonal proliferation of skin-invasive mature T lymphocytes. Because of their low proliferative potential, the accumulation of clonal T cells is considered to be potentially due to their inability to undergo Fas-mediated apoptosis, a crucial process involved in T-cell homeostasis. Several reports have indicated a decrease in or absence of Fas expression in tumor cells in significant proportions of CTCL patients, whether or not associated with overexpression of apoptosis inhibitors. In this issue, Wu et al. confirm the impaired expression of Fas in CTCL cells. Moreover, they show that CTCL cells genetically engineered to re-express Fas acquire a sensitivity to FasL-induced apoptosis, opening new avenues for therapeutic intervention strategies in CTCL.

Abstract

Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin's lymphomas characterized by the clonal proliferation of skin-invasive mature T lymphocytes. Because of their low proliferative potential, the accumulation of clonal T cells is considered to be potentially due to their inability to undergo Fas-mediated apoptosis, a crucial process involved in T-cell homeostasis. Several reports have indicated a decrease in or absence of Fas expression in tumor cells in significant proportions of CTCL patients, whether or not associated with overexpression of apoptosis inhibitors. In this issue, Wu et al. confirm the impaired expression of Fas in CTCL cells. Moreover, they show that CTCL cells genetically engineered to re-express Fas acquire a sensitivity to FasL-induced apoptosis, opening new avenues for therapeutic intervention strategies in CTCL.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2009
Deposited On:08 Mar 2010 07:58
Last Modified:05 Apr 2016 13:52
Publisher:Nature Publishing Group
ISSN:0022-202X
Publisher DOI:https://doi.org/10.1038/jid.2009.14
PubMed ID:19369931

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