Header

UZH-Logo

Maintenance Infos

Cryptococcus gattii meningoencephalitis in an immunocompetent person 13 months after exposure


Georgi, A; Schneemann, M; Tintelnot, K; Calligaris-Maibach, R C; Meyer, S; Weber, R; Bosshard, P P (2009). Cryptococcus gattii meningoencephalitis in an immunocompetent person 13 months after exposure. Infection, 37(4):370-373.

Abstract

A 53-year old immunocompetent Swiss female is described who developed severe meningoencephalitis due to infection with Cryptococcus gattii 13 months following exposure on Vancouver Island, Canada. Diagnosis was based on cerebrospinal fluid (CSF) examination, i.e., positive India-ink staining, positive latex particle agglutination, and positive culture. Species identification was performed by growth on L-canavanine-glycine-bromthymol blue medium and by sequencing of the intergenic and internal transcribed spacer regions of the rRNA genes. After initial therapy with fluconazole by which the patient did not improve, therapy was changed to amphotericin B and flucytosine and later to high-dose fluconazole and amphotericin B. Despite long-term treatment and external drainage of the CSF, the patient's condition improved only slowly. The patient was discharged after 132 days of hospitalization.

Abstract

A 53-year old immunocompetent Swiss female is described who developed severe meningoencephalitis due to infection with Cryptococcus gattii 13 months following exposure on Vancouver Island, Canada. Diagnosis was based on cerebrospinal fluid (CSF) examination, i.e., positive India-ink staining, positive latex particle agglutination, and positive culture. Species identification was performed by growth on L-canavanine-glycine-bromthymol blue medium and by sequencing of the intergenic and internal transcribed spacer regions of the rRNA genes. After initial therapy with fluconazole by which the patient did not improve, therapy was changed to amphotericin B and flucytosine and later to high-dose fluconazole and amphotericin B. Despite long-term treatment and external drainage of the CSF, the patient's condition improved only slowly. The patient was discharged after 132 days of hospitalization.

Statistics

Citations

31 citations in Web of Science®
34 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 15 Feb 2010
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2009
Deposited On:15 Feb 2010 16:31
Last Modified:21 Nov 2017 14:41
Publisher:Springer
ISSN:0300-8126
Publisher DOI:https://doi.org/10.1007/s15010-008-8211-z
PubMed ID:19390780

Download