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Antihistamines are superior to topical steroids in managing Human Immunodeficiency Virus (HIV)-associated papular pruritic eruption


Navarini, A A; Stoeckle, M; Navarini, S; Jullu, B; Mchomvu, R; Mbta, M; Kibatala, K; Tanner, M; Hatz, C; Schmid-Grendelmeier, P (2010). Antihistamines are superior to topical steroids in managing Human Immunodeficiency Virus (HIV)-associated papular pruritic eruption. International Journal of Dermatology, 49(1):83- 86.

Abstract

Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine improved itching (P < 0.0058) and clinical scores (P < 0.032) significantly more than topical steroids. Disease activity did not correlate with CD4+ and CD8+ T cell counts and was independent of anti-retroviral medication. Therefore, oral antihistamines are an effective first-line treatment for PPE.

Abstract

Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine improved itching (P < 0.0058) and clinical scores (P < 0.032) significantly more than topical steroids. Disease activity did not correlate with CD4+ and CD8+ T cell counts and was independent of anti-retroviral medication. Therefore, oral antihistamines are an effective first-line treatment for PPE.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:08 Feb 2010 16:14
Last Modified:05 Apr 2016 13:52
Publisher:Wiley-Blackwell
ISSN:0011-9059
Publisher DOI:https://doi.org/10.1111/j.1365-4632.2009.04279.x
PubMed ID:20465620

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