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Targeting Myc in pediatric malignancies of the central and peripheral nervous system


Grotzer, M A; Castelletti, D; Fiaschetti, G; Shalaby, T; Arcaro, A (2009). Targeting Myc in pediatric malignancies of the central and peripheral nervous system. Current Cancer Drug Targets, 9(2):176-188.

Abstract

Myc family genes are often deregulated in embryonal tumors of childhood including medulloblastoma and neuroblastoma and are frequently associated with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that regulates a variety of cellular processes including cell growth and proliferation, cell cycle progression, differentiation, apoptosis, and cell motility. Potential strategies that either inhibit the proliferation-promoting effect of Myc and/or activate its pro-apoptotic function are presently being explored. In this review, we will give an overview of Myc activation in embryonal tumors and discuss current strategies aimed at targeting Myc for cancer treatment.

Abstract

Myc family genes are often deregulated in embryonal tumors of childhood including medulloblastoma and neuroblastoma and are frequently associated with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that regulates a variety of cellular processes including cell growth and proliferation, cell cycle progression, differentiation, apoptosis, and cell motility. Potential strategies that either inhibit the proliferation-promoting effect of Myc and/or activate its pro-apoptotic function are presently being explored. In this review, we will give an overview of Myc activation in embryonal tumors and discuss current strategies aimed at targeting Myc for cancer treatment.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2009
Deposited On:17 Feb 2010 12:21
Last Modified:18 Feb 2018 00:23
Publisher:Bentham Science
ISSN:1568-0096
OA Status:Closed
Publisher DOI:https://doi.org/10.2174/156800909787580962
Related URLs:http://www.benthamdirect.org/pages/content.php?CCDT/2009/00000009/00000002/0006U.SGM (Publisher)
PubMed ID:19275758

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