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LACTB is a filament-forming protein localized in mitochondria


Polianskyte, Z; Peitsaro, N; Dapkunas, A; Liobikas, J; Soliymani, R; Lalowski, M; Speer, O; Seitsonen, J; Butcher, S; Cereghetti, G; Linder, M; Merckel, M; Thompson, J; Eriksson, O (2009). LACTB is a filament-forming protein localized in mitochondria. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 106(45):18960-18965.

Abstract

LACTB is a mammalian active-site serine protein that has evolved from a bacterial penicillin-binding protein. Penicillin-binding proteins are involved in the metabolism of peptidoglycan, the major bacterial cell wall constituent, implying that LACTB has been endowed with novel biochemical properties during eukaryote evolution. Here we demonstrate that LACTB is localized in the mitochondrial intermembrane space, where it is polymerized into stable filaments with a length extending more than a hundred nanometers. We infer that LACTB, through polymerization, promotes intramitochondrial membrane organization and micro-compartmentalization. These findings have implications for our understanding of mitochondrial evolution and function.

Abstract

LACTB is a mammalian active-site serine protein that has evolved from a bacterial penicillin-binding protein. Penicillin-binding proteins are involved in the metabolism of peptidoglycan, the major bacterial cell wall constituent, implying that LACTB has been endowed with novel biochemical properties during eukaryote evolution. Here we demonstrate that LACTB is localized in the mitochondrial intermembrane space, where it is polymerized into stable filaments with a length extending more than a hundred nanometers. We infer that LACTB, through polymerization, promotes intramitochondrial membrane organization and micro-compartmentalization. These findings have implications for our understanding of mitochondrial evolution and function.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2009
Deposited On:12 Mar 2010 13:55
Last Modified:05 Apr 2016 13:58
Publisher:National Academy of Sciences
ISSN:0027-8424
Free access at:Official URL. An embargo period may apply.
Publisher DOI:https://doi.org/10.1073/pnas.0906734106
Official URL:http://www.pnas.org/content/106/45/18960.long
PubMed ID:19858488

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