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Human and feline invasive cervical resorptions: The missing link? — Presentation of four cases


von Arx, T; Schawalder, P; Ackermann, M; Bosshardt, D D (2009). Human and feline invasive cervical resorptions: The missing link? — Presentation of four cases. Journal of Endodontics, 35(6):904-913.

Abstract

This report describes 4 patients presenting with multiple
teeth affected by invasive cervical resorption (ICR). The
cases came to our attention between 2006 and 2008; previously, no cases ofmultiple ICR (mICR) had been reported in Switzerland. Characteristics common toall4 cases included progression of disease over time, similar clinical and radiographic appearance of lesions, and obscure etiology. The histologically assessed teeth showed a similar pattern of tooth destruction, with resorptive lesions being confined to the cervical region. Howship’s lacunae and multinucleated, tartrate-resistant acid phosphatase–positive odontoclasts were detected. None of the teeth presented with internal resorption. The positive pulp sensitivity corresponded to the histologic findings, indicating that the pulp tissue resisted degradation even in advanced stages of resorptive lesions. Although mICR is rare in humans, a similar disease known as feline odontoclastic resorptive lesions (FORL) is common in domestic, captive, and wild cats. The etiology of FORL, like that of mICR, remains largely unknown. Because FORL has been associated with feline viruses, we asked our mICR patients whether they had had contact with cats, and interestingly, all patients reported having had direct (2 cases) or indirect (2 cases) contact. In addition, blood samples were taken from all patients for neutralization testing of feline herpes virus type 1 (FeHV-1). Indeed, the sera obtained were able to neutralize (2 cases) or partly inhibit (2 cases) replication of FeHV-1, indicating transmission of feline viruses to humans. Future studies on mICR (and FORL) should evaluate the possible role of a (feline) virus as an etiologic (co-)factor in this disease.

Abstract

This report describes 4 patients presenting with multiple
teeth affected by invasive cervical resorption (ICR). The
cases came to our attention between 2006 and 2008; previously, no cases ofmultiple ICR (mICR) had been reported in Switzerland. Characteristics common toall4 cases included progression of disease over time, similar clinical and radiographic appearance of lesions, and obscure etiology. The histologically assessed teeth showed a similar pattern of tooth destruction, with resorptive lesions being confined to the cervical region. Howship’s lacunae and multinucleated, tartrate-resistant acid phosphatase–positive odontoclasts were detected. None of the teeth presented with internal resorption. The positive pulp sensitivity corresponded to the histologic findings, indicating that the pulp tissue resisted degradation even in advanced stages of resorptive lesions. Although mICR is rare in humans, a similar disease known as feline odontoclastic resorptive lesions (FORL) is common in domestic, captive, and wild cats. The etiology of FORL, like that of mICR, remains largely unknown. Because FORL has been associated with feline viruses, we asked our mICR patients whether they had had contact with cats, and interestingly, all patients reported having had direct (2 cases) or indirect (2 cases) contact. In addition, blood samples were taken from all patients for neutralization testing of feline herpes virus type 1 (FeHV-1). Indeed, the sera obtained were able to neutralize (2 cases) or partly inhibit (2 cases) replication of FeHV-1, indicating transmission of feline viruses to humans. Future studies on mICR (and FORL) should evaluate the possible role of a (feline) virus as an etiologic (co-)factor in this disease.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2009
Deposited On:02 Mar 2010 14:41
Last Modified:18 Feb 2018 00:43
Publisher:Elsevier
ISSN:0099-2399
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.joen.2009.03.044
PubMed ID:19482196

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