Header

UZH-Logo

Maintenance Infos

Interaction of novel metal complexes with DNA: synthetic and structural aspects


Spingler, B; Da Pieve, C; Medina-Molner, A; Antoni, P M; Santangelo, M G (2009). Interaction of novel metal complexes with DNA: synthetic and structural aspects. CHIMIA International Journal for Chemistry, 63(3):153-156.

Abstract

Metal ions bind to nucleic acids at various positions. This binding can be modulated by using metal complexes with appropriate ligands. Novel mono- and especially dinuclear metal complexes could be a powerful tool to detect rare, but still physiologically relevant, forms of DNA, e.g. the left-handed Z-DNA. In this review, our recent research activities in this area of bioinorganic chemistry are summarized. A special emphasis is laid on the synthetic challenges that arose upon the synthesis of the polyamine ligands. Further, some rather unusual approaches to elucidate the solution structure of copper bound to guanosine monophosphate with the help of pulsed EPR techniques like ENDOR and HYSCORE are described.

Abstract

Metal ions bind to nucleic acids at various positions. This binding can be modulated by using metal complexes with appropriate ligands. Novel mono- and especially dinuclear metal complexes could be a powerful tool to detect rare, but still physiologically relevant, forms of DNA, e.g. the left-handed Z-DNA. In this review, our recent research activities in this area of bioinorganic chemistry are summarized. A special emphasis is laid on the synthetic challenges that arose upon the synthesis of the polyamine ligands. Further, some rather unusual approaches to elucidate the solution structure of copper bound to guanosine monophosphate with the help of pulsed EPR techniques like ENDOR and HYSCORE are described.

Statistics

Citations

7 citations in Web of Science®
7 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

81 downloads since deposited on 12 Mar 2010
6 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:March 2009
Deposited On:12 Mar 2010 08:20
Last Modified:26 Jan 2017 08:46
Publisher:Swiss Chemical Society
ISSN:0009-4293
Additional Information:Copyright ©Swiss Chemical Society: CHIMIA, Volume 63, Number 3, March 2009 , pp. 153-156
Publisher DOI:https://doi.org/10.2533/chimia.2009.153

Download

Preview Icon on Download
Preview
Filetype: PDF
Size: 1MB
View at publisher