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Analyzing effective connectivity with fMRI


Stephan, K E; Friston, K J (2010). Analyzing effective connectivity with fMRI. Wiley Interdisciplinary Reviews: Cognitive Science, 1(3):446-459.

Abstract

Functional neuroimaging techniques are used widely in cognitive neuroscience to investigate aspects of functional specialization and functional integration in the human brain. Functional integration can be characterized in two ways, functional connectivity and effective connectivity. While functional connectivity describes statistical dependencies between data, effective connectivity rests on a mechanistic model of the causal effects that generated the data. This review addresses the conceptual and methodological basis of established techniques for characterizing effective connectivity using functional magnetic resonance imaging (fMRI) data. In particular, we focus on dynamic causal modeling (DCM) of fMRI data and emphasize the importance of model selection procedures and nonlinear mechanisms for context-dependent changes in connection strengths.

Abstract

Functional neuroimaging techniques are used widely in cognitive neuroscience to investigate aspects of functional specialization and functional integration in the human brain. Functional integration can be characterized in two ways, functional connectivity and effective connectivity. While functional connectivity describes statistical dependencies between data, effective connectivity rests on a mechanistic model of the causal effects that generated the data. This review addresses the conceptual and methodological basis of established techniques for characterizing effective connectivity using functional magnetic resonance imaging (fMRI) data. In particular, we focus on dynamic causal modeling (DCM) of fMRI data and emphasize the importance of model selection procedures and nonlinear mechanisms for context-dependent changes in connection strengths.

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56 citations in Web of Science®
58 citations in Scopus®
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104 downloads since deposited on 12 Jul 2010
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:03 Faculty of Economics > Department of Economics
08 University Research Priority Programs > Foundations of Human Social Behavior: Altruism and Egoism
Dewey Decimal Classification:170 Ethics
330 Economics
Language:English
Date:May 2010
Deposited On:12 Jul 2010 15:22
Last Modified:05 Apr 2016 14:10
Publisher:Wiley-Blackwell
ISSN:1939-5078
Publisher DOI:https://doi.org/10.1002/wcs.58

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