Header

UZH-Logo

Maintenance Infos

Extraintestinal Crohn's Disease Mimicking Autoimmune Inner Ear Disease: A Histopathological Approach


Dettmer, M; Hegemann, I; Hegemann, S C A (2010). Extraintestinal Crohn's Disease Mimicking Autoimmune Inner Ear Disease: A Histopathological Approach. Audiology and Neurotology, 16(1):36-40.

Abstract

Patients with autoimmune inner ear disease develop rapidly progressive sensorineural hearing loss over a period of several weeks or months, often accompanied by vestibular loss. This disease can occur as a distinct clinical entity or in association with an underlying autoimmune disorder. Treatment comprises immunosuppression by corticosteroids, cytostatic drugs or tumor necrosis factor-alpha antagonists. We report histopathological and immunohistochemical findings of the inner ear of a patient with a granulomatous inner ear disease suffering from Crohn's disease that was nonresponsive to treatment and who underwent surgery for bilateral cochlear implants.

Abstract

Patients with autoimmune inner ear disease develop rapidly progressive sensorineural hearing loss over a period of several weeks or months, often accompanied by vestibular loss. This disease can occur as a distinct clinical entity or in association with an underlying autoimmune disorder. Treatment comprises immunosuppression by corticosteroids, cytostatic drugs or tumor necrosis factor-alpha antagonists. We report histopathological and immunohistochemical findings of the inner ear of a patient with a granulomatous inner ear disease suffering from Crohn's disease that was nonresponsive to treatment and who underwent surgery for bilateral cochlear implants.

Statistics

Citations

3 citations in Web of Science®
4 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

279 downloads since deposited on 06 Jul 2010
68 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:06 Jul 2010 14:44
Last Modified:01 Jul 2016 10:18
Publisher:Karger
ISSN:1420-3030
Publisher DOI:https://doi.org/10.1159/000315063
PubMed ID:20523038

Download

Preview Icon on Download
Preview
Filetype: PDF
Size: 291kB
View at publisher
Preview Icon on Download
Preview
Content: Published Version
Filetype: PDF
Size: 724kB