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Novel candidate substrates of AMP-activated protein kinase identified in red blood cell lysates


Thali, R F; Tuerk, R D; Scholz, R; Yoho-Auchli, Y; Brunisholz, R A; Neumann, D (2010). Novel candidate substrates of AMP-activated protein kinase identified in red blood cell lysates. Biochemical and Biophysical Research Communications (BBRC), 398(2):296-301.

Abstract

AMPK is a metabolic stress-sensing kinase with important functions for red blood cell (RBC) survival. By using a proteomic approach, we identified putative AMPK targets in hemoglobin-depleted lysates of RBC, including metabolic enzymes, cytoskeletal proteins and enzymes involved in the oxidative stress response. These data tie in with the phenotypic observations of AMPKalpha1-deficient RBC and provide reference for future studies.

Abstract

AMPK is a metabolic stress-sensing kinase with important functions for red blood cell (RBC) survival. By using a proteomic approach, we identified putative AMPK targets in hemoglobin-depleted lysates of RBC, including metabolic enzymes, cytoskeletal proteins and enzymes involved in the oxidative stress response. These data tie in with the phenotypic observations of AMPKalpha1-deficient RBC and provide reference for future studies.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Functional Genomics Center Zurich
08 University Research Priority Programs > Systems Biology / Functional Genomics
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2010
Deposited On:04 Nov 2010 16:35
Last Modified:07 Dec 2017 03:15
Publisher:Elsevier
ISSN:0006-291X
Publisher DOI:https://doi.org/10.1016/j.bbrc.2010.06.084
PubMed ID:20599718

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