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Risk-benefit assessment in medical research--critical review and open questions


Rid (Schulz-Baldes), A; Wendler, D (2010). Risk-benefit assessment in medical research--critical review and open questions. Law, Probability and Risk, 9(3-4):151-177.

Abstract

One of the central ethical requirements for medical research is that the risks to individual research participants should not be excessive. Despite widespread endorsement of this requirement, how it should be implemented remains controversial. This paper critically reviews the four existing approaches to evaluating the risks and benefits of medical research. It argues that the ‘net risks test’ is superior to ‘component analysis’, the ‘agreement principle’, and the ‘integrative approach’ and ends by highlighting several important questions that remain to be addressed.

Abstract

One of the central ethical requirements for medical research is that the risks to individual research participants should not be excessive. Despite widespread endorsement of this requirement, how it should be implemented remains controversial. This paper critically reviews the four existing approaches to evaluating the risks and benefits of medical research. It argues that the ‘net risks test’ is superior to ‘component analysis’, the ‘agreement principle’, and the ‘integrative approach’ and ends by highlighting several important questions that remain to be addressed.

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Additional indexing

Item Type:Journal Article, not refereed, original work
Communities & Collections:01 Faculty of Theology > Center for Ethics
04 Faculty of Medicine > Institute of Biomedical Ethics and History of Medicine
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2010
Deposited On:19 Nov 2010 16:47
Last Modified:05 Apr 2016 14:16
Publisher:Oxford University Press
ISSN:1470-8396
Publisher DOI:https://doi.org/10.1093/lpr/mgq006

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