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Salt bridges and conformational flexibility: effect on protein stability


Karshikoff, A; Jelesarov, I (2008). Salt bridges and conformational flexibility: effect on protein stability. Biotechnology and Biotechnological Equipment, 22(1):606-611.

Abstract

Salt bridges are believed to have an important role in stabilisation of native protein structure. The assessment of their contribution to the electrostatic term of the free energy is a yet unsolved task. One can point out a number of reasons: beginning with conceptual issues, such as the complex nature of the interplay between the different types of non-covalent interactions and going to details, such as the interactions of the participating groups with their environments. Here we focus on the interplay between electrostatic interactions the functional groups forming salt bridges are involved in and the conformational flexibility of the protein molecule. We show that the connection between these two factors appears to be one of the keys for a better understanding of the forces determining stability of proteins.

Abstract

Salt bridges are believed to have an important role in stabilisation of native protein structure. The assessment of their contribution to the electrostatic term of the free energy is a yet unsolved task. One can point out a number of reasons: beginning with conceptual issues, such as the complex nature of the interplay between the different types of non-covalent interactions and going to details, such as the interactions of the participating groups with their environments. Here we focus on the interplay between electrostatic interactions the functional groups forming salt bridges are involved in and the conformational flexibility of the protein molecule. We show that the connection between these two factors appears to be one of the keys for a better understanding of the forces determining stability of proteins.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:February 2008
Deposited On:22 Sep 2008 08:38
Last Modified:05 Apr 2016 12:28
Publisher:Diagnosis Press
ISSN:1310-2818
Publisher DOI:https://doi.org/10.1080/13102818.2008.10817520
Official URL:http://www.diagnosisp.com/dp/journals/view_abstract_ref.php?journal_id=1&archive=0&issue_id=17&article_id=471&PHPSESSID=58730fd4acdc37ccccbb8db4353f2544
Related URLs:http://www.diagnosisp.com/dp/journals/issue.php?journal_id=1&archive=0&issue_id=17&PHPSESSID=58730fd4acdc37ccccbb8db4353f2544 (Publisher)

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