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Erosion-inhibiting potential of a stannous chloride-containing fluoride solution under acid flow conditions in vitro


Yu, Hao; Wegehaupt, Florian J; Zaruba, Markus; Becker, Klaus; Roos, Malgorzata; Attin, Thomas; Wiegand, Annette (2010). Erosion-inhibiting potential of a stannous chloride-containing fluoride solution under acid flow conditions in vitro. Archives of Oral Biology, 55(9):702-705.

Abstract

OBJECTIVES: This study aimed to analyse the erosion-inhibiting potential of a single application of stannous chloride-containing fluoride solution on pellicle-covered enamel and dentine under constant acid flow conditions in vitro. DESIGN: Bovine enamel (n=60) and dentine (n=60) samples were exposed 1h to the oral cavity of 4 healthy volunteers to allow for in situ pellicle formation. Pellicle-covered samples were randomly assigned to three groups (each n=20 enamel and n=20 dentine samples; 5 enamel and 5 dentine samples/volunteer) and treated once with a SnCl2/AmF/NaF (800 ppm Sn(II), 500 ppm F, pH 4.5) or a NaF solution (500 ppm F, pH 4.5) for 2 min or remained untreated (controls). Samples were eroded with hydrochloric acid (pH 2.6) in a small erosion chamber at 60 microl/min for 25 min. Calcium release into the acid was monitored in consecutive 30s intervals for 5 min, then at 1 min intervals up to a total erosion time of 25 min using the Arsenazo III procedure. Data were statistically analysed by random-effects linear models (p<0.05). RESULTS: The stannous chloride-containing fluoride solution reduced calcium loss of enamel and dentine to up to 6 min and 3.5 min, respectively. Calcium loss (% of control) amounted from 24+/-7 (30s) up to 93+/-14 (6 min) in enamel and from 38+/-13 (30s) to 87+/-15 (3.5 min) in dentine. The sodium fluoride solution was unable to reduce enamel and dentine erosion at any time point. CONCLUSION: A single application of a stannous chloride-containing fluoride solution reduced enamel and dentine erosion up to 6 min and 3.5 min of constant acid flow, respectively.

Abstract

OBJECTIVES: This study aimed to analyse the erosion-inhibiting potential of a single application of stannous chloride-containing fluoride solution on pellicle-covered enamel and dentine under constant acid flow conditions in vitro. DESIGN: Bovine enamel (n=60) and dentine (n=60) samples were exposed 1h to the oral cavity of 4 healthy volunteers to allow for in situ pellicle formation. Pellicle-covered samples were randomly assigned to three groups (each n=20 enamel and n=20 dentine samples; 5 enamel and 5 dentine samples/volunteer) and treated once with a SnCl2/AmF/NaF (800 ppm Sn(II), 500 ppm F, pH 4.5) or a NaF solution (500 ppm F, pH 4.5) for 2 min or remained untreated (controls). Samples were eroded with hydrochloric acid (pH 2.6) in a small erosion chamber at 60 microl/min for 25 min. Calcium release into the acid was monitored in consecutive 30s intervals for 5 min, then at 1 min intervals up to a total erosion time of 25 min using the Arsenazo III procedure. Data were statistically analysed by random-effects linear models (p<0.05). RESULTS: The stannous chloride-containing fluoride solution reduced calcium loss of enamel and dentine to up to 6 min and 3.5 min, respectively. Calcium loss (% of control) amounted from 24+/-7 (30s) up to 93+/-14 (6 min) in enamel and from 38+/-13 (30s) to 87+/-15 (3.5 min) in dentine. The sodium fluoride solution was unable to reduce enamel and dentine erosion at any time point. CONCLUSION: A single application of a stannous chloride-containing fluoride solution reduced enamel and dentine erosion up to 6 min and 3.5 min of constant acid flow, respectively.

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
04 Faculty of Medicine > Center for Dental Medicine > Clinic for Preventive Dentistry, Periodontology and Cariology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:15 Nov 2010 09:33
Last Modified:05 Apr 2016 14:24
Publisher:Elsevier
ISSN:0003-9969
Publisher DOI:https://doi.org/10.1016/j.archoralbio.2010.06.006
PubMed ID:20627197

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