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What goes in must come out - the small intestine modulates renal phosphate excretion


Wagner, C A; Biber, J; Murer, H (2007). What goes in must come out - the small intestine modulates renal phosphate excretion. Nephrology, Dialysis, Transplantation, 22(12):3411-3412.

Abstract

In a recent article in PNAS, Berndt et al. describe a novel and rapid regulation of renal phosphate excretion by phosphate instilled into the small intestine [1]. In a series of elegant experiments, renal phosphate clearance was measured before and during the infusion of a small amount of phosphate into the distal duodenum of rats. Twenty minutes after the infusion, massive phosphaturia was observed. This effect was specific for phosphate and was not seen when phosphate was instilled into the stomach or when NaCl was applied. Phosphaturia occurred without a measurable increase in serum phosphate and . . .

Abstract

In a recent article in PNAS, Berndt et al. describe a novel and rapid regulation of renal phosphate excretion by phosphate instilled into the small intestine [1]. In a series of elegant experiments, renal phosphate clearance was measured before and during the infusion of a small amount of phosphate into the distal duodenum of rats. Twenty minutes after the infusion, massive phosphaturia was observed. This effect was specific for phosphate and was not seen when phosphate was instilled into the stomach or when NaCl was applied. Phosphaturia occurred without a measurable increase in serum phosphate and . . .

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:December 2007
Deposited On:19 Mar 2009 17:57
Last Modified:06 Dec 2017 14:26
Publisher:Oxford University Press
ISSN:0931-0509
Publisher DOI:https://doi.org/10.1093/ndt/gfm554
PubMed ID:18042617

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Content: Accepted Version
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