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Expression and putative functions of GDF-15, a member of the TGF-β superfamily, in human glioma and glioblastoma cell lines


Strelau, J; Schmeer, C; Peterziel, H; Sackmann, T; Herold-Mende, C; Steinert, H; Weller, M; Unsicker, K (2008). Expression and putative functions of GDF-15, a member of the TGF-β superfamily, in human glioma and glioblastoma cell lines. Cancer Letters, 270(1):30-39.

Abstract

Recent studies have demonstrated growth-inhibiting effects of growth differentiation factor-15 (GDF-15) on different cancer cell lines invitro and on tumor growth in vivo. Here, we present data concerning expression of GDF-15 in glioblastoma. We found low levels of GDF-15 transcripts in primary glioblastoma. Thus, GDF-15 expression might be exploited as a useful indicator for distinguishing primary from other glial derived tumors. In contrast to the documented proapoptotic and anti-tumorigenic activities of GDF-15 in several cancer cell lines, our data suggest that GDF-15 does not decrease proliferation of glioblastoma cell lines, while its effects on invasiveness are not consistent.

Abstract

Recent studies have demonstrated growth-inhibiting effects of growth differentiation factor-15 (GDF-15) on different cancer cell lines invitro and on tumor growth in vivo. Here, we present data concerning expression of GDF-15 in glioblastoma. We found low levels of GDF-15 transcripts in primary glioblastoma. Thus, GDF-15 expression might be exploited as a useful indicator for distinguishing primary from other glial derived tumors. In contrast to the documented proapoptotic and anti-tumorigenic activities of GDF-15 in several cancer cell lines, our data suggest that GDF-15 does not decrease proliferation of glioblastoma cell lines, while its effects on invasiveness are not consistent.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:18 October 2008
Deposited On:07 Nov 2008 14:10
Last Modified:05 Apr 2016 12:28
Publisher:Elsevier
ISSN:0304-3835
Publisher DOI:https://doi.org/10.1016/j.canlet.2008.04.042
PubMed ID:18550273

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