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Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus Type-1 gp120 glycoprotein complexed to CD4


Seitz, M; Rusert, P; Moehle, K; Trkola, A; Robinson, J A (2010). Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus Type-1 gp120 glycoprotein complexed to CD4. Chemical Communications, 46(41):7754-7756.

Abstract

A helical tyrosine-sulfated epitope in CCR5 that is recognized by the human immunodeficiency virus type-1 envelope glycoprotein gp120 in its CD4-induced conformation can be mimicked structurally by a cyclic ß-hairpin peptide containing two sulfated tyrosine residues at positons i and i+2 along one ß-strand.

Abstract

A helical tyrosine-sulfated epitope in CCR5 that is recognized by the human immunodeficiency virus type-1 envelope glycoprotein gp120 in its CD4-induced conformation can be mimicked structurally by a cyclic ß-hairpin peptide containing two sulfated tyrosine residues at positons i and i+2 along one ß-strand.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2010
Deposited On:24 Jan 2011 14:49
Last Modified:18 Apr 2018 11:41
Publisher:Royal Society of Chemistry
ISSN:1359-7345
Funders:SNF
OA Status:Green
Publisher DOI:https://doi.org/10.1039/C0CC02913K
PubMed ID:20830376
Project Information:
  • : FunderSNSF
  • : Grant ID
  • : Project TitleSNF

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