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G-quadruplex-modulated fluorescence detection of potassium in the presence of a 3500-fold excess of sodium ions


Qin, H; Ren, J; Wang, J; Luedtke, N; Wang, E (2010). G-quadruplex-modulated fluorescence detection of potassium in the presence of a 3500-fold excess of sodium ions. Analytical Chemistry, 82(19):8356-8360.

Abstract

A label-free detection of K+ was developed using G-quadruplex DNA (c-Myc) modulated fluorescence enhancement of tetrakis-(diisopropylguanidino) zinc phthalocyanine (Zn-DIGP). Upon the addition of increasing concentrations of potassium, a detection limit of 0.8 μM for K+ was easily achieved. Comparative titrations using sodium, lithium, ammonium, transition metal, or alkali earth salts revealed that the fluorescence enhancement was highly specific for potassium ions. This system has, for the first time, provided a means for detecting 40 μM of K+ even in the presence of a 3500-fold excess of Na+ ions.

Abstract

A label-free detection of K+ was developed using G-quadruplex DNA (c-Myc) modulated fluorescence enhancement of tetrakis-(diisopropylguanidino) zinc phthalocyanine (Zn-DIGP). Upon the addition of increasing concentrations of potassium, a detection limit of 0.8 μM for K+ was easily achieved. Comparative titrations using sodium, lithium, ammonium, transition metal, or alkali earth salts revealed that the fluorescence enhancement was highly specific for potassium ions. This system has, for the first time, provided a means for detecting 40 μM of K+ even in the presence of a 3500-fold excess of Na+ ions.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2010
Deposited On:18 Feb 2011 20:18
Last Modified:16 Jan 2018 08:06
Publisher:American Chemical Society
ISSN:0003-2700
Publisher DOI:https://doi.org/10.1021/ac101894b
PubMed ID:20804164

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