Header

UZH-Logo

Maintenance Infos

Neural crest-derived stem cells


Shakhova, O; Sommer, L (2010). Neural crest-derived stem cells. In: The Stem Cell Research Community. StemBook. Cambridge: Harvard Stem Cell Institute, Online.

Abstract

The neural crest is a transient embryonic structure in vertebrates that gives rise to most of the peripheral nervous system (PNS) and to several non-neural cell types, including smooth muscle cells of the cardiovascular system, pigment cells in the skin, and craniofacial bones, cartilage, and connective tissue. Although neural crest cells undergo developmental restrictions with time, at least some neural crest cells have the capacity to self-renew and display a developmental potential almost only topped by embryonic stem (ES) cells. Intriguingly, such neural crest-derived stem cells (NCSCs) are not only present in the embryonic neural crest, but also in various neural crest-derived tissues in the fetal and even adult organism. These postmigratory NCSCs functionally resemble their embryonic counterparts in their ability to differentiate into a variety of cell types. Because of their broad potential, the possibility to isolate NCSCs from easily accessible tissue, and the recent accomplishment to generate NCSC-like cells from human ES and induced pluripotent stem (iPS) cells, NCSCs have become an ideal model system to study stem cell biology in development and disease. Despite exciting achievements in the field, several pressing issues remain to be addressed, however, such as the mechanisms regulating expansion and fate decisions in NCSCs from different sources and the still unknown physiological roles of NCSCs in the adult organism.

Abstract

The neural crest is a transient embryonic structure in vertebrates that gives rise to most of the peripheral nervous system (PNS) and to several non-neural cell types, including smooth muscle cells of the cardiovascular system, pigment cells in the skin, and craniofacial bones, cartilage, and connective tissue. Although neural crest cells undergo developmental restrictions with time, at least some neural crest cells have the capacity to self-renew and display a developmental potential almost only topped by embryonic stem (ES) cells. Intriguingly, such neural crest-derived stem cells (NCSCs) are not only present in the embryonic neural crest, but also in various neural crest-derived tissues in the fetal and even adult organism. These postmigratory NCSCs functionally resemble their embryonic counterparts in their ability to differentiate into a variety of cell types. Because of their broad potential, the possibility to isolate NCSCs from easily accessible tissue, and the recent accomplishment to generate NCSC-like cells from human ES and induced pluripotent stem (iPS) cells, NCSCs have become an ideal model system to study stem cell biology in development and disease. Despite exciting achievements in the field, several pressing issues remain to be addressed, however, such as the mechanisms regulating expansion and fate decisions in NCSCs from different sources and the still unknown physiological roles of NCSCs in the adult organism.

Statistics

Altmetrics

Downloads

121 downloads since deposited on 01 Feb 2011
10 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Anatomy
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2010
Deposited On:01 Feb 2011 13:34
Last Modified:05 Apr 2016 14:37
Publisher:Harvard Stem Cell Institute
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3824/stembook.1.51.1
PubMed ID:20614636

Download

Preview Icon on Download
Preview
Filetype: PDF
Size: 2MB
View at publisher

Article Networks

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations