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Sleep-wake disturbances 3 years after traumatic brain injury


Kempf, J; Werth, E; Kaiser, P R; Bassetti, C L; Baumann, C R (2010). Sleep-wake disturbances 3 years after traumatic brain injury. Journal of Neurology, Neurosurgery, and Psychiatry, 81(12):1402-1405.

Abstract

BACKGROUND: 6 months after traumatic brain injury (TBI), almost three out of four patients suffer from sleep-wake disturbances (SWD) such as post-traumatic hypersomnia (increased sleep need of ≥2 h compared with before injury), excessive daytime sleepiness (EDS), fatigue and insomnia. The long-term course of post-traumatic SWD, however, is unknown.

OBJECTIVES: To assess the prevalence and characteristics of post-traumatic SWD 3 years after trauma.

DESIGN: Prospective longitudinal clinical study in 51 consecutive TBI patients (43 males, eight females, mean age 40±16 years).

MAIN OUTCOME MEASURES: EDS (as assessed by the Epworth sleepiness scale), fatigue (fatigue severity scale), post-traumatic hypersomnia (sleep length per 24 h), insomnia, depression and anxiety.

RESULTS: Post-traumatic SWD were found in 34 patients (67%): post-traumatic hypersomnia in 14 (27%), EDS in six (12%), fatigue in 18 patients (35%) and insomnia in five patients (10%). SWD were not associated with severity or localisation of, or time interval since, TBI. Insomnia was linked to depressive symptoms.

CONCLUSIONS: This prospective study shows that 3 years after TBI, two out of three patients suffer from residual SWD, particularly fatigue and post-traumatic hypersomnia. In 45% of TBI patients, SWD appear directly related to the trauma itself.

Abstract

BACKGROUND: 6 months after traumatic brain injury (TBI), almost three out of four patients suffer from sleep-wake disturbances (SWD) such as post-traumatic hypersomnia (increased sleep need of ≥2 h compared with before injury), excessive daytime sleepiness (EDS), fatigue and insomnia. The long-term course of post-traumatic SWD, however, is unknown.

OBJECTIVES: To assess the prevalence and characteristics of post-traumatic SWD 3 years after trauma.

DESIGN: Prospective longitudinal clinical study in 51 consecutive TBI patients (43 males, eight females, mean age 40±16 years).

MAIN OUTCOME MEASURES: EDS (as assessed by the Epworth sleepiness scale), fatigue (fatigue severity scale), post-traumatic hypersomnia (sleep length per 24 h), insomnia, depression and anxiety.

RESULTS: Post-traumatic SWD were found in 34 patients (67%): post-traumatic hypersomnia in 14 (27%), EDS in six (12%), fatigue in 18 patients (35%) and insomnia in five patients (10%). SWD were not associated with severity or localisation of, or time interval since, TBI. Insomnia was linked to depressive symptoms.

CONCLUSIONS: This prospective study shows that 3 years after TBI, two out of three patients suffer from residual SWD, particularly fatigue and post-traumatic hypersomnia. In 45% of TBI patients, SWD appear directly related to the trauma itself.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:24 June 2010
Deposited On:26 Jan 2011 18:21
Last Modified:05 Apr 2016 14:39
Publisher:BMJ Publishing Group
ISSN:0022-3050
Additional Information:Comment in: J Neurol Neurosurg Psychiatry. 2010 Dec;81(12):1297.
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1136/jnnp.2009.201913
PubMed ID:20884672

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