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Phosphate transport in the kidney


Murer, H; Biber, J (2010). Phosphate transport in the kidney. Journal of Nephrology, 23 Sup(S16):S145-S151.

Abstract

In kidneys of mammals, filtered phosphate ions (Pi) are reabsorbed along the proximal tubules. Transcellular transport of phosphate is initiated by several apically localized sodium-dependent Pi cotransporters (Na/Pi-cotransporters) that belong to the SLC 20 (SLC20A2) and 34 (SLC34A1, SLC34A3) families. Apical abundance of these Na/Pi-cotransporters is adjusted by numerous hormones/phosphatonins and metabolic factors in order to adjust the extent of renal Pi reabsorption according to body needs. Acute hormonal regulation of Pi reabsorption occurs mainly by a change of the abundance of SLC34A1 (NaPi-IIa) via modulation of the interaction of NaPi-IIa with the PDZ-protein NHERF1.

Abstract

In kidneys of mammals, filtered phosphate ions (Pi) are reabsorbed along the proximal tubules. Transcellular transport of phosphate is initiated by several apically localized sodium-dependent Pi cotransporters (Na/Pi-cotransporters) that belong to the SLC 20 (SLC20A2) and 34 (SLC34A1, SLC34A3) families. Apical abundance of these Na/Pi-cotransporters is adjusted by numerous hormones/phosphatonins and metabolic factors in order to adjust the extent of renal Pi reabsorption according to body needs. Acute hormonal regulation of Pi reabsorption occurs mainly by a change of the abundance of SLC34A1 (NaPi-IIa) via modulation of the interaction of NaPi-IIa with the PDZ-protein NHERF1.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology

04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:December 2010
Deposited On:15 Feb 2011 13:16
Last Modified:21 Nov 2017 15:17
Publisher:Wichtig Editore
ISSN:1121-8428
Related URLs:http://www.jnephrol.com/public/JN/default.aspx (Publisher)
PubMed ID:21170872

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