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INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells


Bonner, C; Bacon, S; Concannon, C G; Rizvi, S R; Baquié, M; Farrelly, A M; Kilbride, S M; Dussmann, H; Ward, M W; Boulanger, C M; Wollheim, C B; Graf, R; Byrne, M M; Prehn, J H M (2010). INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells. Diabetes, 59(11):2799-2808.

Abstract

Our results suggest that apoptosing INS-1 cells shed microparticles that may stimulate PSP/reg induction in neighboring cells, a mechanism that may facilitate the recovery of β-cell mass in HNF1A-MODY.

Abstract

Our results suggest that apoptosing INS-1 cells shed microparticles that may stimulate PSP/reg induction in neighboring cells, a mechanism that may facilitate the recovery of β-cell mass in HNF1A-MODY.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:14 Apr 2011 09:28
Last Modified:12 Aug 2017 02:29
Publisher:American Diabetes Association
ISSN:0012-1797
Additional Information:The accepted manuscript is an author-created, uncopyedited electronic version of an article accepted for publication in Diabetes (http://diabetes.diabetesjournals.org). The American Diabetes Association (ADA), publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version is available online at DOI 10.2337/db09-1478.
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.2337/db09-1478
PubMed ID:20682686

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