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Therapeutic drug monitoring by LC-MS-MS with special focus on anti-infective drugs


Müller, D M; Rentsch, K M (2010). Therapeutic drug monitoring by LC-MS-MS with special focus on anti-infective drugs. Analytical and Bioanalytical Chemistry, 398(6):2573-2594.

Abstract

Liquid chromatography coupled to mass spectrometry nowadays plays an important role in the field of therapeutic drug monitoring (TDM), especially of new compounds for which no immunoassays are available. This paper reviews LC-MS(-MS) methods published recently for anti-infective drugs: antiretroviral drugs, other antiviral drugs, antibacterial drugs, antihelmintic drugs, antimalarial drugs, and other antiprotozoal drugs. An overview of the different methods is given, with special focus on selection of the internal standard and validation procedures.

Abstract

Liquid chromatography coupled to mass spectrometry nowadays plays an important role in the field of therapeutic drug monitoring (TDM), especially of new compounds for which no immunoassays are available. This paper reviews LC-MS(-MS) methods published recently for anti-infective drugs: antiretroviral drugs, other antiviral drugs, antibacterial drugs, antihelmintic drugs, antimalarial drugs, and other antiprotozoal drugs. An overview of the different methods is given, with special focus on selection of the internal standard and validation procedures.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Clinical Chemistry
Dewey Decimal Classification:610 Medicine & health
540 Chemistry
Language:English
Date:2010
Deposited On:16 Feb 2011 09:50
Last Modified:05 Apr 2016 14:47
Publisher:Springer
ISSN:1618-2642
Publisher DOI:https://doi.org/10.1007/s00216-010-3986-z
PubMed ID:20652551

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