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Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation


Garuti, C; Tian, Y; Montosi, G; Sabelli, M; Corradini, E; Graf, R; Ventura, P; Vegetti, A; Clavien, P A; Pietrangelo, A (2010). Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation. Gastroenterology, 139(1):315-322.e1.

Abstract

In Hfe(-/-) mice, transplantation of livers from Hfe(+/+) mice reversed the iron-loading phenotype associated with hemochromatosis (regardless of Hfe expression in intestine). However, KCs still had low levels of iron that were not affected by hepatic hepcidin expression. These findings indicate an independent, iron-modifying effect of HFE in KCs.

Abstract

In Hfe(-/-) mice, transplantation of livers from Hfe(+/+) mice reversed the iron-loading phenotype associated with hemochromatosis (regardless of Hfe expression in intestine). However, KCs still had low levels of iron that were not affected by hepatic hepcidin expression. These findings indicate an independent, iron-modifying effect of HFE in KCs.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Visceral and Transplantation Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:14 Apr 2011 09:19
Last Modified:05 Apr 2016 14:47
Publisher:Elsevier
ISSN:0016-5085
Publisher DOI:https://doi.org/10.1053/j.gastro.2010.03.043
PubMed ID:20338170

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