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Redox-induced binding of [(tacn)Re(II)Br(CO)2]+ to guanine, oligonucleotides, and peptides


Zobi, F; Alberto, R (2010). Redox-induced binding of [(tacn)Re(II)Br(CO)2]+ to guanine, oligonucleotides, and peptides. Chemistry - A European Journal, 16(9):2710-2713.

Abstract

Oxidation is the key: A redox-switch based on a water-soluble ReII complex is presented. Upon binding to biological ligands such as the side chains in peptides or proteins, ReII in, for example, [ReII(tacn)(L)(CO)2]2+ (in wich L=target site, TACN = 1,4,7-triazacyclononane), becomes strongly oxidizing and is reduced to the robust ReI complex [ReI(tacn)(L)(CO)2]+. This reduction leads to essentially irreversible metalation of the biomolecule.

Abstract

Oxidation is the key: A redox-switch based on a water-soluble ReII complex is presented. Upon binding to biological ligands such as the side chains in peptides or proteins, ReII in, for example, [ReII(tacn)(L)(CO)2]2+ (in wich L=target site, TACN = 1,4,7-triazacyclononane), becomes strongly oxidizing and is reduced to the robust ReI complex [ReI(tacn)(L)(CO)2]+. This reduction leads to essentially irreversible metalation of the biomolecule.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Uncontrolled Keywords:biomolecule; labelling; oligonucteotide; peptide; rhenium
Language:English
Date:2010
Deposited On:24 Feb 2011 18:44
Last Modified:05 Apr 2016 14:48
Publisher:Wiley-Blackwell
ISSN:0947-6539
Publisher DOI:https://doi.org/10.1002/chem.200902760
PubMed ID:20135650
Other Identification Number:ISI:000275943000010

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