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Remission of diabetes mellitus in cats cannot be predicted by the arginine stimulation test


Tschuor, F. Remission of diabetes mellitus in cats cannot be predicted by the arginine stimulation test. 2011, University of Zurich, Vetsuisse Faculty.

Abstract

Background: Responsiveness of β-cells to arginine persists the longest during diabetes
progression, making the intravenous arginine stimulation test (IVAST) a useful tool to assess
residual insulin and glucagon secretion. Hypothesis: Diabetic cats with and without remission
will have different arginine-induced insulin or glucagon response. Animals: 17 cats with
diabetes, 7 healthy cats. Methods: Response to IVAST was assessed by calculating insulin
and glucagon area under the curve (AUC) and the AUC glucagon:insulin ratio. Diabetic cats
were treated with insulin and followed for 18 weeks. Remission was defined as
normoglycemia and disappearance of clinical signs of diabetes for ≥4 weeks. Results: 7
diabetic cats achieved remission. On admission, blood glucose concentration was significantly
lower in cats with remission (median, 389 mg/dL) than in those without remission (median,
506 mg/dL). After IVAST, diabetic cats with remission had higher AUC glucagon:insulin
ratios (median, 61) than did cats without remission (median, 26); glucose, insulin, and
glucagon AUCs were not different. Diabetic cats had lower insulin AUC than did healthy cats
but comparable glucagon AUC. Conclusions: Diabetic cats with and without remission have
similar arginine-stimulated insulin secretion. Although cats with remission had lower blood
glucose concentrations and higher AUC glucagon:insulin ratios, large overlap between groups
prevents use of these parameters in practice.

Abstract

Background: Responsiveness of β-cells to arginine persists the longest during diabetes
progression, making the intravenous arginine stimulation test (IVAST) a useful tool to assess
residual insulin and glucagon secretion. Hypothesis: Diabetic cats with and without remission
will have different arginine-induced insulin or glucagon response. Animals: 17 cats with
diabetes, 7 healthy cats. Methods: Response to IVAST was assessed by calculating insulin
and glucagon area under the curve (AUC) and the AUC glucagon:insulin ratio. Diabetic cats
were treated with insulin and followed for 18 weeks. Remission was defined as
normoglycemia and disappearance of clinical signs of diabetes for ≥4 weeks. Results: 7
diabetic cats achieved remission. On admission, blood glucose concentration was significantly
lower in cats with remission (median, 389 mg/dL) than in those without remission (median,
506 mg/dL). After IVAST, diabetic cats with remission had higher AUC glucagon:insulin
ratios (median, 61) than did cats without remission (median, 26); glucose, insulin, and
glucagon AUCs were not different. Diabetic cats had lower insulin AUC than did healthy cats
but comparable glucagon AUC. Conclusions: Diabetic cats with and without remission have
similar arginine-stimulated insulin secretion. Although cats with remission had lower blood
glucose concentrations and higher AUC glucagon:insulin ratios, large overlap between groups
prevents use of these parameters in practice.

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Additional indexing

Item Type:Dissertation
Referees:Reusch C E, Lutz T A
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Language:English
Date:2011
Deposited On:18 Apr 2011 11:38
Last Modified:12 Aug 2017 14:00
Additional Information:Vorzeitig publiziert in und Sonderdruck aus: Journal of Veterinary Internal Medicine, 25(1):83-89
Related URLs:http://opac.nebis.ch/F/?local_base=NEBIS&CON_LNG=GER&func=find-b&find_code=SYS&request=006410901
http://www.zora.uzh.ch/40500/

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