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Temsirolimus is highly effective as third-line treatment in chromophobe renal cell cancer


Zardavas, Dimitrios; Meisel, Alexander; Samaras, P; Knuth, Alexander; Renner, Christoph; Pestalozzi, Bernhard C; Stenner-Liewen, Frank (2011). Temsirolimus is highly effective as third-line treatment in chromophobe renal cell cancer. Case Reports in Oncology, 4(1):16-18.

Abstract

We report unexpectedly high efficacy of temsirolimus as third-line treatment in a patient with metastatic chromophobe renal cell carcinoma. After failure of two sequentially administered tyrosine kinase inhibitors, treatment with temsirolimus resulted in a prolonged partial remission of 14 months, and the response is still continuing. Up to now, no data from randomized clinical studies have been published addressing the question of efficacy of temsirolimus as third-line treatment after failure of tyrosine kinase inhibitors. The case presented here implies that temsirolimus could be a viable option for patients with metastatic chromophobe renal cell carcinoma.

Abstract

We report unexpectedly high efficacy of temsirolimus as third-line treatment in a patient with metastatic chromophobe renal cell carcinoma. After failure of two sequentially administered tyrosine kinase inhibitors, treatment with temsirolimus resulted in a prolonged partial remission of 14 months, and the response is still continuing. Up to now, no data from randomized clinical studies have been published addressing the question of efficacy of temsirolimus as third-line treatment after failure of tyrosine kinase inhibitors. The case presented here implies that temsirolimus could be a viable option for patients with metastatic chromophobe renal cell carcinoma.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Chromophobe renal cell cancer; Liver metastases; Sorafenib; Sunitinib; Temsirolimus
Language:English
Date:2011
Deposited On:06 May 2011 11:15
Last Modified:25 Aug 2017 16:17
Publisher:Karger
ISSN:1662-6575
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1159/000323804
PubMed ID:21526001

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