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Antineoplastic activity of taurolidine and its derivatives on human ex vivo glioblastoma bulk cells and cancer stem cells


Kälin, M B. Antineoplastic activity of taurolidine and its derivatives on human ex vivo glioblastoma bulk cells and cancer stem cells. 2010, University of Zurich, Faculty of Medicine.

Abstract

Despite multimodal therapy, patients suffering from glioblastoma (GBM) still have a dismal prognosis. The identification of cancer stem cells (CSC) in brain tumour tissue, yielded hope that the vulnerable target to combat GBM has been found. Several study groups worldwide concentrate nowadays on therapeutic strategies that effectively target CSC. Since in our laboratory has been revealed that taurolidine, a derivate of the amino acid taurin, displays a potent antineoplastic effect in human glioma cell lines and in ex vivo malignant cell culture, this thesis focused on the susceptibility of glioblastoma CSC to taurolidine and temozolomide (TMZ), the most commonly used chemotherapeutic agent so far. Additionally, we investigated the most powerful derivative of taurolidine and tested its antineoplastic activity on CSC as well.

Abstract

Despite multimodal therapy, patients suffering from glioblastoma (GBM) still have a dismal prognosis. The identification of cancer stem cells (CSC) in brain tumour tissue, yielded hope that the vulnerable target to combat GBM has been found. Several study groups worldwide concentrate nowadays on therapeutic strategies that effectively target CSC. Since in our laboratory has been revealed that taurolidine, a derivate of the amino acid taurin, displays a potent antineoplastic effect in human glioma cell lines and in ex vivo malignant cell culture, this thesis focused on the susceptibility of glioblastoma CSC to taurolidine and temozolomide (TMZ), the most commonly used chemotherapeutic agent so far. Additionally, we investigated the most powerful derivative of taurolidine and tested its antineoplastic activity on CSC as well.

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Additional indexing

Item Type:Dissertation
Referees:Bertalanffy H, Frei K
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurosurgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:09 Jun 2011 12:01
Last Modified:07 Dec 2017 08:26

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