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Quality of life following brainstem cavernoma surgery in 71 patients


Dukatz, T; Sarnthein, J; Sitter, H; Bozinov, O; Benes, L; Sure, U; Bertalanffy, H (2011). Quality of life following brainstem cavernoma surgery in 71 patients. Neurosurgery, 69(3):689-695.

Abstract

BACKGROUND: Symptomatic patients harboring a brainstem cavernoma are treated surgically with increasing frequency. Generally, the patient's benefit from this difficult surgical intervention is quantified by the assessment of neurological symptoms.

OBJECTIVE: To document the beneficial effect of surgery in a larger patient population by assessing the postoperative quality of life (QoL).

METHODS: In a series of 71 surgically treated patients, a detailed neurological status was assessed by Patzold Rating and Karnofsky Performance Status Scale (KPS). Patients rated their QoL with the SF-36 questionnaire. To document the effect of surgery on QoL, we devised a supplementary questionnaire. The last 24 patients completed SF-36 pre- and postoperatively.

RESULTS: KPS improved in 44 of 71 surgical patients (62%), remained unchanged in 19 (27%) and deteriorated in 8 (11%) individuals. Patzold Rating showed a more detailed picture of the neurological symptoms. It correlated significantly with KPS, which underlines its usefulness for patients with brainstem lesions. In the SF-36 score the Mental Component Summary (MCS) improved with surgery (paired test, p = 0.015). In addition, 58 individuals (82%) declared a clear subjective benefit of surgery.

CONCLUSION: The results of this large series support the notion that microsurgical removal of a brainstem cavernoma represents an effective therapy in experienced hands, and is generally associated with good clinical outcome, both neurologically and in terms of QoL.

Abstract

BACKGROUND: Symptomatic patients harboring a brainstem cavernoma are treated surgically with increasing frequency. Generally, the patient's benefit from this difficult surgical intervention is quantified by the assessment of neurological symptoms.

OBJECTIVE: To document the beneficial effect of surgery in a larger patient population by assessing the postoperative quality of life (QoL).

METHODS: In a series of 71 surgically treated patients, a detailed neurological status was assessed by Patzold Rating and Karnofsky Performance Status Scale (KPS). Patients rated their QoL with the SF-36 questionnaire. To document the effect of surgery on QoL, we devised a supplementary questionnaire. The last 24 patients completed SF-36 pre- and postoperatively.

RESULTS: KPS improved in 44 of 71 surgical patients (62%), remained unchanged in 19 (27%) and deteriorated in 8 (11%) individuals. Patzold Rating showed a more detailed picture of the neurological symptoms. It correlated significantly with KPS, which underlines its usefulness for patients with brainstem lesions. In the SF-36 score the Mental Component Summary (MCS) improved with surgery (paired test, p = 0.015). In addition, 58 individuals (82%) declared a clear subjective benefit of surgery.

CONCLUSION: The results of this large series support the notion that microsurgical removal of a brainstem cavernoma represents an effective therapy in experienced hands, and is generally associated with good clinical outcome, both neurologically and in terms of QoL.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurosurgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:09 Jun 2011 12:07
Last Modified:05 Apr 2016 14:55
Publisher:Lippincott Wiliams & Wilkins
ISSN:0148-396X
Additional Information:This is a non-final version of an article published in final form in Dukatz, T; Sarnthein, J; Sitter, H; Bozinov, O; Benes, L; Sure, U; Bertalanffy, H (2011). Quality of life following brainstem cavernoma surgery in 71 patients. Neurosurgery, 69(3):689-695..
Publisher DOI:https://doi.org/10.1227/Neu.Ob013e31821d31b7
PubMed ID:21508880

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