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Intratumoral plasmacytoid dendritic cells associate with increased survival in patients with follicular lymphoma.


Butsch, R; Waelti, S L; Schaerer, S; Braun, J; Korol, D; Probst-Hensch, N; Moch, H; Kurrer, M (2011). Intratumoral plasmacytoid dendritic cells associate with increased survival in patients with follicular lymphoma. Leukemia and Lymphoma, 52(7):1230-1238.

Abstract

Gene array studies on follicular lymphoma (FL) have associated non-malignant tumor-infiltrating immune cells with patient survival. We examined the role of such cells detectable by immunohistochemistry in a tissue microarray, focusing on plasmacytoid dendritic cells (pDCs). These cells physiologically produce interferon-α, which has been used in the therapy of FL. High numbers of pDCs are associated with increased survival, and so are high numbers of CD3+ T cells. The regular distribution of pDCs within T cell areas is reflected by a weak but significant correlation between pDCs and T cells. However, in multivariate Cox models, CD123 proved to be an independent prognostic factor. These findings support the hypothesis of an association of pDCs with better prognosis by producing interferon. Furthermore, due to a linear relationship between pDCs and survival shown by means of Kaplan-Meier plots, immunohistochemical staining of CD123 could serve as a prognostic tool for patients with FL.

Abstract

Gene array studies on follicular lymphoma (FL) have associated non-malignant tumor-infiltrating immune cells with patient survival. We examined the role of such cells detectable by immunohistochemistry in a tissue microarray, focusing on plasmacytoid dendritic cells (pDCs). These cells physiologically produce interferon-α, which has been used in the therapy of FL. High numbers of pDCs are associated with increased survival, and so are high numbers of CD3+ T cells. The regular distribution of pDCs within T cell areas is reflected by a weak but significant correlation between pDCs and T cells. However, in multivariate Cox models, CD123 proved to be an independent prognostic factor. These findings support the hypothesis of an association of pDCs with better prognosis by producing interferon. Furthermore, due to a linear relationship between pDCs and survival shown by means of Kaplan-Meier plots, immunohistochemical staining of CD123 could serve as a prognostic tool for patients with FL.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:24 Jun 2011 10:29
Last Modified:07 Dec 2017 08:31
Publisher:Informa Healthcare
ISSN:1026-8022
Additional Information:This is an electronic version of an article published in Leukemia and Lymphoma, 52(7):1230-1238. Leukemia and Lymphoma is available online at: http://informahealthcare.com/journal/lal.
Publisher DOI:https://doi.org/10.3109/10428194.2011.569619
PubMed ID:21599580

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