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Functional magnetic resonance imaging investigation of the amphetamine sensitization model of schizophrenia in healthy male volunteers


O'Daly, Owen G; Joyce, Daniel; Stephan, Klaas E; Murray, Robin M G; Shergill, Sukhwinder S (2011). Functional magnetic resonance imaging investigation of the amphetamine sensitization model of schizophrenia in healthy male volunteers. Archives of General Psychiatry, 68(6):545-554.

Abstract

These transient load-dependent abnormalities of frontal and temporal activity induced by amphetamine sensitization support neuroimaging findings in schizophrenic patients, implying that amphetamine sensitization may help to bridge pathophysiological theories of schizophrenia that focus on pharmacological (dopaminergic) and cognitive mechanisms, respectively.

Abstract

These transient load-dependent abnormalities of frontal and temporal activity induced by amphetamine sensitization support neuroimaging findings in schizophrenic patients, implying that amphetamine sensitization may help to bridge pathophysiological theories of schizophrenia that focus on pharmacological (dopaminergic) and cognitive mechanisms, respectively.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
08 University Research Priority Programs > Foundations of Human Social Behavior: Altruism and Egoism
Dewey Decimal Classification:170 Ethics
330 Economics
Language:English
Date:2011
Deposited On:14 Jul 2011 13:13
Last Modified:07 Dec 2017 08:37
Publisher:American Medical Association
ISSN:0003-990X
Publisher DOI:https://doi.org/10.1001/archgenpsychiatry.2011.3
PubMed ID:21300940

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