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Immunotherapy concepts under investigation


Kündig, T M (2011). Immunotherapy concepts under investigation. Allergy, 66(s95):60-62.

Abstract

To cite this article: Kündig TM. Immunotherapy concepts under investigation. Allergy 2011; 66 (Suppl. 95): 60-62. ABSTRACT: Allergen-specific immunotherapy (SIT) is effective, but used by only 5% of allergy patients, partly because it requires several years. Intralymphatic immunotherapy (ILIT) administers allergen directly into a subcutaneous lymph node and requires only three injections and a lower allergen dose than subcutaneous administration. ILIT was further improved using a recombinant allergen with enhanced uptake and decreased degradation by antigen-presenting cells. Another interesting route is transcutaneous/epicutaneous immunotherapy (TCIT, EPIT), which administers allergen by a skin patch. Clinical trials show that TCIT, EPIT is safe and comparably effective to conventional immunotherapy. Implementation of these new methods would increase the spectrum of SIT options, allowing greater individual choice of SIT.

Abstract

To cite this article: Kündig TM. Immunotherapy concepts under investigation. Allergy 2011; 66 (Suppl. 95): 60-62. ABSTRACT: Allergen-specific immunotherapy (SIT) is effective, but used by only 5% of allergy patients, partly because it requires several years. Intralymphatic immunotherapy (ILIT) administers allergen directly into a subcutaneous lymph node and requires only three injections and a lower allergen dose than subcutaneous administration. ILIT was further improved using a recombinant allergen with enhanced uptake and decreased degradation by antigen-presenting cells. Another interesting route is transcutaneous/epicutaneous immunotherapy (TCIT, EPIT), which administers allergen by a skin patch. Clinical trials show that TCIT, EPIT is safe and comparably effective to conventional immunotherapy. Implementation of these new methods would increase the spectrum of SIT options, allowing greater individual choice of SIT.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:04 Aug 2011 10:58
Last Modified:05 Apr 2016 14:58
Publisher:Wiley-Blackwell
ISSN:0105-4538
Publisher DOI:https://doi.org/10.1111/j.1398-9995.2011.02643.x
PubMed ID:21668859

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