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Immunotherapy of Alzheimer disease


Nitsch, R M (2004). Immunotherapy of Alzheimer disease. Alzheimer Disease and Associated Disorders, 18(4):185-189.

Abstract

Optimism regarding the treatment and prevention of Alzheimer disease has begun to replace the attitude of therapeutic nihilism that clouded the field for so many decades. Neurotransmitter-based therapy with AChEls and NMDA receptor antagonists are now in current use; anti-inflammatory and anti-oxidative approaches as well as compounds to block Abeta aggregation are being tested in the clinic; beta- and gamma-secretase inhibitors designed to reduce generation of Abeta peptides are under development. One of the more provocative developments in this field was the idea of vaccination against beta-amyloid. Despite vivid antagonism that was rapidly voiced by many concerned experts, there are actually several excellent reasons why brain beta-amyloid plaques are attractive immunotherapeutic targets for the treatment and prevention of AD.

Abstract

Optimism regarding the treatment and prevention of Alzheimer disease has begun to replace the attitude of therapeutic nihilism that clouded the field for so many decades. Neurotransmitter-based therapy with AChEls and NMDA receptor antagonists are now in current use; anti-inflammatory and anti-oxidative approaches as well as compounds to block Abeta aggregation are being tested in the clinic; beta- and gamma-secretase inhibitors designed to reduce generation of Abeta peptides are under development. One of the more provocative developments in this field was the idea of vaccination against beta-amyloid. Despite vivid antagonism that was rapidly voiced by many concerned experts, there are actually several excellent reasons why brain beta-amyloid plaques are attractive immunotherapeutic targets for the treatment and prevention of AD.

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14 citations in Web of Science®
17 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2004
Deposited On:02 Sep 2011 08:24
Last Modified:16 Aug 2016 10:15
Publisher:Lippincott Wiliams & Wilkins
ISSN:0893-0341
PubMed ID:15592128

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