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Endocrine disturbances in depression


Tichomirowa, M A; Keck, M E; Schneider, H J; Paez-Pereda, M; Renner, U; Holsboer, F; Stalla, G K (2005). Endocrine disturbances in depression. Journal of Endocrinological Investigation, 28(1):89-99.

Abstract

Depression is one of the most common psychiatric disorders. For a long time, clinicians suspected a causal link between depression and the endocrine system. The most frequently occurring endocrine abnormality in depressed subjects is hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. CRH and AVP are likely to play a substantial role in the pathophysiology of this disorder, and their receptors appear to be a specific target for future antidepressant drugs. Depression also affects the hypothalamic-pituitary-GH (HPGH) and -thyroid (HPT) axes. Alterations in the reproductive system may also play a role in the pathology of depression. In addition, there is increasing evidence that leptin and neurosteroids, such as DHEA, are implicated in mood disorders.

Abstract

Depression is one of the most common psychiatric disorders. For a long time, clinicians suspected a causal link between depression and the endocrine system. The most frequently occurring endocrine abnormality in depressed subjects is hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. CRH and AVP are likely to play a substantial role in the pathophysiology of this disorder, and their receptors appear to be a specific target for future antidepressant drugs. Depression also affects the hypothalamic-pituitary-GH (HPGH) and -thyroid (HPT) axes. Alterations in the reproductive system may also play a role in the pathology of depression. In addition, there is increasing evidence that leptin and neurosteroids, such as DHEA, are implicated in mood disorders.

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65 citations in Web of Science®
79 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2005
Deposited On:05 Sep 2011 08:40
Last Modified:16 Aug 2016 10:14
Publisher:Kurtis - Italian Society of Endocrinology
ISSN:0391-4097
Publisher DOI:https://doi.org/10.1007/BF03345535
Official URL:http://www.jendocrinolinvest.it/jei/en/abstract.cfm?articolo_id=2914
PubMed ID:15816377

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