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A functional genetic variation of the 5-HT2a receptor affects human memory


de Quervain, D J F; Henke, K; Aerni, A; Coluccia, D; Wollmer, M A; Hock, C; Nitsch, R M; Papassotiropoulos, A (2003). A functional genetic variation of the 5-HT2a receptor affects human memory. Nature Neuroscience, 6(11):1141-1142.

Abstract

Human memory capacity is highly variable across individuals and is influenced by both genetic and environmental factors. A roughly 50% heritability estimate indicates that naturally occurring genetic variations have an important impact on this cognitive ability. Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant.

Abstract

Human memory capacity is highly variable across individuals and is influenced by both genetic and environmental factors. A roughly 50% heritability estimate indicates that naturally occurring genetic variations have an important impact on this cognitive ability. Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2003
Deposited On:08 Sep 2011 06:31
Last Modified:16 Aug 2016 10:15
Publisher:Nature Publishing Group
ISSN:1097-6256
Publisher DOI:https://doi.org/10.1038/nn1146
PubMed ID:14566344

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