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Individualized quantification of brain β-amyloid burden: results of a proof of mechanism phase 0 florbetaben PET trial in patients with Alzheimer's disease and healthy controls


Barthel, H; Luthardt, J; Becker, G; Patt, M; Hammerstein, E; Hartwig, K; Eggers, B; Sattler, B; Schildan, A; Hesse, S; Meyer, P M; Wolf, H; Zimmermann, T; Reischl, J; Rohde, B; Gertz, H J; Reininger, C; Sabri, O (2011). Individualized quantification of brain β-amyloid burden: results of a proof of mechanism phase 0 florbetaben PET trial in patients with Alzheimer's disease and healthy controls. European Journal of Nuclear Medicine and Molecular Imaging, 38(9):1702-1714.

Abstract

These results indicate florbetaben to be a safe and efficacious β-amyloid-targeted tracer with favourable brain kinetics. Subjects with AD could be easily differentiated from HCs by both visual and quantitative assessment of the PET data. The operator-independent, voxel-based analysis yielded whole brain β-amyloid load which appeared valuable as a surrogate marker of disease severity.

Abstract

These results indicate florbetaben to be a safe and efficacious β-amyloid-targeted tracer with favourable brain kinetics. Subjects with AD could be easily differentiated from HCs by both visual and quantitative assessment of the PET data. The operator-independent, voxel-based analysis yielded whole brain β-amyloid load which appeared valuable as a surrogate marker of disease severity.

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50 citations in Web of Science®
56 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:13 Sep 2011 14:35
Last Modified:07 Dec 2017 09:02
Publisher:Springer
ISSN:1619-7070
Publisher DOI:https://doi.org/10.1007/s00259-011-1821-1
PubMed ID:21547601

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