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Conditional CRF receptor 1 knockout mice show altered neuronal activation pattern to mild anxiogenic challenge


Nguyen, N K; Keck, M E; Hetzenauer, A; Thoeringer, C K; Wurst, W; Deussing, J M; Holsboer, F; Müller, M B; Singewald, N (2006). Conditional CRF receptor 1 knockout mice show altered neuronal activation pattern to mild anxiogenic challenge. Psychopharmacology, 188(3):374-385.

Abstract

These results underline the importance of limbic CRF-R1 in modulating anxiety-related behavior and suggest that reduced neuronal activation in the identified limbic and hypothalamic key structures of the anxiety circuitry may mediate or contribute to the anxiolytic-like phenotype observed in mice with region-specific deletion of forebrain CRF-R1.

Abstract

These results underline the importance of limbic CRF-R1 in modulating anxiety-related behavior and suggest that reduced neuronal activation in the identified limbic and hypothalamic key structures of the anxiety circuitry may mediate or contribute to the anxiolytic-like phenotype observed in mice with region-specific deletion of forebrain CRF-R1.

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25 citations in Web of Science®
24 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2006
Deposited On:18 Oct 2011 07:41
Last Modified:07 Dec 2017 09:10
Publisher:Springer
ISSN:0033-3158
Publisher DOI:https://doi.org/10.1007/s00213-006-0513-1
PubMed ID:16953386

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