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Isolated central nervous system relapse of systemic lymphoma (SCNSL): clinical features and outcome of a retrospective analysis


Patrij, K; Reiser, M; Wätzel, L; Pels, H; Kowoll, A; Herrlinger, U; Engert, A; Linnebank, M; Schackert, G; Vogt-Schaden, M; Egerer, G; Lamprecht, M; Batchelor, T T; Schlegel, U; Schmidt-Wolf, I G H (2011). Isolated central nervous system relapse of systemic lymphoma (SCNSL): clinical features and outcome of a retrospective analysis. German Medical Science, 9:Doc11.

Abstract

We analyzed clinical outcome of patients with an isolated central nervous system lymphoma (CNSL) relapse after systemic non-Hodgkin's lymphoma (NHL). All 23 patients with an isolated secondary CNSL (SCNSL) treated at two institutions from 04/2003-12/2007 were included into this analysis. At cerebral relapse, 15/23 patients were treated with a regimen consisting of high-dose methotrexate (Bonn protocol). After a median follow-up of 6.5 months (range 1-68), 15/23 (65%) patients with SCNSL had relapsed or progressed. HD (high-dose)- methotrexate (MTX) chemotherapy according to the Bonn protocol is effective concerning response rates; however, overall survival of patients with SCNSL seems to be impaired in comparison to relapses in primary CNSL (PCNSL).

Abstract

We analyzed clinical outcome of patients with an isolated central nervous system lymphoma (CNSL) relapse after systemic non-Hodgkin's lymphoma (NHL). All 23 patients with an isolated secondary CNSL (SCNSL) treated at two institutions from 04/2003-12/2007 were included into this analysis. At cerebral relapse, 15/23 patients were treated with a regimen consisting of high-dose methotrexate (Bonn protocol). After a median follow-up of 6.5 months (range 1-68), 15/23 (65%) patients with SCNSL had relapsed or progressed. HD (high-dose)- methotrexate (MTX) chemotherapy according to the Bonn protocol is effective concerning response rates; however, overall survival of patients with SCNSL seems to be impaired in comparison to relapses in primary CNSL (PCNSL).

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Additional indexing

Other titles:Isoliertes Zentralnervensystem-Rezidiv eines systemischen Lymphoms: Klinische Merkmale und Verlauf einer retrospektiven Analyse
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Date:2011
Deposited On:10 Nov 2011 11:19
Last Modified:07 Aug 2017 01:46
Publisher:Association of the Scientific Medical Societies in Germany
ISSN:1612-3174
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.3205/000134
PubMed ID:21698087
Other Identification Number:urn:nbn:de:0183-0001348

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