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Predicting an allograft's fate


Fehr, T; Cohen, C D (2011). Predicting an allograft's fate. Kidney International, 80(12):1254-1255.

Abstract

Renal allografts inevitably develop progressive morphological and functional deterioration.
Naesens et al. now report on a transcriptomic approach to identify transcriptional markers
that might predict rapid development of chronic damage even in histologically unremarkable
allografts. The data indicate that similar processes as seen in overt acute rejection are also
involved in chronic allograft nephropathy. Identifying such “sub-morphological” markers
should help to better understand biological processes leading to chronic allograft failure.

Abstract

Renal allografts inevitably develop progressive morphological and functional deterioration.
Naesens et al. now report on a transcriptomic approach to identify transcriptional markers
that might predict rapid development of chronic damage even in histologically unremarkable
allografts. The data indicate that similar processes as seen in overt acute rejection are also
involved in chronic allograft nephropathy. Identifying such “sub-morphological” markers
should help to better understand biological processes leading to chronic allograft failure.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nephrology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2011
Deposited On:17 Nov 2011 08:49
Last Modified:17 Feb 2018 13:57
Publisher:Nature Publishing Group
ISSN:0085-2538
OA Status:Closed
Publisher DOI:https://doi.org/10.1038/ki.2011.328
PubMed ID:22126981

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