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Validation of the Zürich burn-biofilm model


Guggenheim, M; Thurnheer, T; Gmür, R; Giovanoli, P; Guggenheim, B (2011). Validation of the Zürich burn-biofilm model. Burns, 37(7):1125-1133.

Abstract

The polyspecies biofilm model contains the most prevalent burn-associated Gram-positive and Gram-negative bacterial pathogens and mimics the Gram-negative shift observed in vivo. It shows excellent reproducibility. It should allow adaptation to the bacterial spectrum prevalent in different burn centres and lead to a much more reliable investigation of the efficiency of topical antimicrobial agents than models operating with planktonic bacteria. The experiments further open up the perspective to create an in vivo model using these biofilms as infectious agents.

Abstract

The polyspecies biofilm model contains the most prevalent burn-associated Gram-positive and Gram-negative bacterial pathogens and mimics the Gram-negative shift observed in vivo. It shows excellent reproducibility. It should allow adaptation to the bacterial spectrum prevalent in different burn centres and lead to a much more reliable investigation of the efficiency of topical antimicrobial agents than models operating with planktonic bacteria. The experiments further open up the perspective to create an in vivo model using these biofilms as infectious agents.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
04 Faculty of Medicine > Center for Dental Medicine > Institute of Oral Biology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Reconstructive Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:12 Dec 2011 14:02
Last Modified:05 Apr 2016 15:12
Publisher:Elsevier
ISSN:0305-4179
Publisher DOI:https://doi.org/10.1016/j.burns.2011.05.017
PubMed ID:21724333

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