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Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport


Svoboda, M; Wlcek, K; Taferner, B; Hering, S; Stieger, B; Tong, D; Zeillinger, R; Thalhammer, T; Jäger, W (2011). Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport. Biomedicine & pharmacotherapy, 65(6):417-426.

Abstract

Our results revealed OATP1B1 and OATP1B3 as high-affinity paclitaxel transporters expressed in ovarian cancer cell lines and tumor tissues, suggesting a role for these polypeptides in the disposition of paclitaxel during therapy.

Abstract

Our results revealed OATP1B1 and OATP1B3 as high-affinity paclitaxel transporters expressed in ovarian cancer cell lines and tumor tissues, suggesting a role for these polypeptides in the disposition of paclitaxel during therapy.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2011
Deposited On:16 Dec 2011 12:35
Last Modified:17 Feb 2018 14:07
Publisher:Éditions Scientifiques Elsevier
ISSN:0753-3322
OA Status:Green
Publisher DOI:https://doi.org/10.1016/j.biopha.2011.04.031
PubMed ID:21719246

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