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The role of FXR in disorders of bile acid homeostasis


Eloranta, J J; Kullak-Ublick, G A (2008). The role of FXR in disorders of bile acid homeostasis. Physiology, 23:286-295.

Abstract

As ligands for the nuclear receptor FXR, bile acids regulate their own synthesis, transport, and conjugation, thus protecting against bile acid toxicity. Recently, the role of genetic variants in FXR itself, FXR target genes, and regulators of FXR in the pathophysiology of the liver and intestine has become increasingly evident.

Abstract

As ligands for the nuclear receptor FXR, bile acids regulate their own synthesis, transport, and conjugation, thus protecting against bile acid toxicity. Recently, the role of genetic variants in FXR itself, FXR target genes, and regulators of FXR in the pathophysiology of the liver and intestine has become increasingly evident.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2008
Deposited On:11 Nov 2008 07:47
Last Modified:06 Dec 2017 14:59
Publisher:American Physiological Society
ISSN:1548-9221
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1152/physiol.00020.2008
PubMed ID:18927204

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