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Hepatic hemangiomas: Difference in enhancement pattern on 3T MR imaging with gadobenate dimeglumine versus gadoxetate disodium


Gupta, R T; Marin, D; Boll, D T; Husarik, D B; Davis, D E; Feuerlein, S; Merkle, E M (2012). Hepatic hemangiomas: Difference in enhancement pattern on 3T MR imaging with gadobenate dimeglumine versus gadoxetate disodium. European Journal of Radiology, 81(10):2457-2462.

Abstract

PURPOSE: To compare intraindividual differences in enhancement pattern of hepatic hemangiomas between gadobenate dimeglumine (Gd-BOPTA) and gadoxetate disodium (Gd-EOB-DTPA)-enhanced 3T MR imaging. MATERIALS AND METHODS: This is a HIPAA-compliant, IRB-approved retrospective study with waiver for informed consent granted. From 10/07 to 5/09, 10 patients (2 males, 8 females; mean age, 57.3 years) with 15 hepatic hemangiomas (mean diameter, 4.4±5.6cm) underwent both Gd-BOPTA- and Gd-EOB-DTPA-enhanced 3T MR imaging (mean interval, 266 days; range, 38-462 days). Diagnosis of hemangioma was based on strict imaging criteria. MR imaging was obtained during three arterial, portal venous, and up to four delayed phases. During each phase, hemangioma-to-liver contrast-to-noise ratio (CNR) was measured for each lesion on both examinations. Statistical analysis was performed using paired Student's t-test. RESULTS: Hemangioma-to-liver CNR peaked during the portal venous phase (Gd-BOPTA: 48.9±65.8, Gd-EOB-DTPA: 0.7±3.8). During all imaging phases except the first arterial phase, hemangioma-to-liver CNR was significantly lower on Gd-EOB-DTPA-enhanced compared to Gd-BOPTA-enhanced MR images (p<0.05). Notably, Gd-EOB-DTPA yielded negative hemangioma-to-liver CNR (-2.5±2.4) compared to Gd-BOPTA (40.7±56.4) during the first delayed phase (7-8min after contrast administration), remaining negative for the rest of the delayed phases (up to 26min after contrast administration). CONCLUSION: The enhancement patterns of hepatic hemangiomas differs significantly between Gd-BOPTA and Gd-EOB-DTPA-enhanced 3T MR imaging. The smaller dose, shorter plasma half-life, and increased hepatobiliary uptake of Gd-EOB-DTPA leads to a negative CNR of hemangioma-to-liver on delayed phases and could create an imaging pitfall with this agent.

Abstract

PURPOSE: To compare intraindividual differences in enhancement pattern of hepatic hemangiomas between gadobenate dimeglumine (Gd-BOPTA) and gadoxetate disodium (Gd-EOB-DTPA)-enhanced 3T MR imaging. MATERIALS AND METHODS: This is a HIPAA-compliant, IRB-approved retrospective study with waiver for informed consent granted. From 10/07 to 5/09, 10 patients (2 males, 8 females; mean age, 57.3 years) with 15 hepatic hemangiomas (mean diameter, 4.4±5.6cm) underwent both Gd-BOPTA- and Gd-EOB-DTPA-enhanced 3T MR imaging (mean interval, 266 days; range, 38-462 days). Diagnosis of hemangioma was based on strict imaging criteria. MR imaging was obtained during three arterial, portal venous, and up to four delayed phases. During each phase, hemangioma-to-liver contrast-to-noise ratio (CNR) was measured for each lesion on both examinations. Statistical analysis was performed using paired Student's t-test. RESULTS: Hemangioma-to-liver CNR peaked during the portal venous phase (Gd-BOPTA: 48.9±65.8, Gd-EOB-DTPA: 0.7±3.8). During all imaging phases except the first arterial phase, hemangioma-to-liver CNR was significantly lower on Gd-EOB-DTPA-enhanced compared to Gd-BOPTA-enhanced MR images (p<0.05). Notably, Gd-EOB-DTPA yielded negative hemangioma-to-liver CNR (-2.5±2.4) compared to Gd-BOPTA (40.7±56.4) during the first delayed phase (7-8min after contrast administration), remaining negative for the rest of the delayed phases (up to 26min after contrast administration). CONCLUSION: The enhancement patterns of hepatic hemangiomas differs significantly between Gd-BOPTA and Gd-EOB-DTPA-enhanced 3T MR imaging. The smaller dose, shorter plasma half-life, and increased hepatobiliary uptake of Gd-EOB-DTPA leads to a negative CNR of hemangioma-to-liver on delayed phases and could create an imaging pitfall with this agent.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:20 Dec 2011 12:37
Last Modified:05 Apr 2016 15:14
Publisher:Elsevier
ISSN:0720-048X
Publisher DOI:https://doi.org/10.1016/j.ejrad.2011.10.014
PubMed ID:22138122

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