Header

UZH-Logo

Maintenance Infos

Contrast-enhanced magnetic resonance angiography: First-pass arterial enhancement as a function of gadolinium-chelate concentration, and the saline chaser volume and injection rate


Husarik, D B; Bashir, M R; Weber, P W; Nichols, E B; Howle, L E; Merkle, E M; Nelson, R C (2012). Contrast-enhanced magnetic resonance angiography: First-pass arterial enhancement as a function of gadolinium-chelate concentration, and the saline chaser volume and injection rate. Investigative Radiology, 47(2):121-127.

Abstract

OBJECTIVE:: To evaluate the effect of the contrast medium (CM) concentration and the saline chaser volume and injection rate on first-pass aortic enhancement characteristics in contrast-enhanced magnetic resonance angiography using a physiologic flow phantom. MATERIALS AND METHODS:: Imaging was performed on a 3.0-T magnetic resonance system (MAGNETOM Trio, Siemens Healthcare Solutions, Inc, Erlangen, Germany) using a 2-dimensional fast low angle shot T1-weighted sequence (repetition time, 500 milliseconds; echo time, 1.23 milliseconds; flip angle, 8 degrees; 1 frame/s × 60 seconds). The following CM concentrations injected at 2 mL/s were used with 3 different contrast agents (gadolinium [Gd]-BOPTA, Gd-HP-DO3A, Gd-DTPA): 20 mL of undiluted CM (100%) and 80%, 40%, 20%, 10%, 5%, and 2.5% of the full amount, all diluted in saline to a volume of 20 mL to ensure equal bolus volume. The CM was followed by saline chasers of 20 to 60 mL injected at 2 mL/s and 6 mL/s. Aortic signal intensity (SI) was measured, and normalized SI versus time (SI/Tn) curves were generated. The maximal SI (SImax), bolus length, and areas under the SI/Tn curve were calculated. RESULTS:: Decreasing the CM concentration from 100% to 40% resulted in a decrease of SImax to 86.1% (mean). Further decreasing the CM concentration to 2.5% decreased SImax to 5.1% (mean). Altering the saline chaser volume had no significant effect on SImax. Increasing the saline chaser injection rate had little effect (mean increase, 2.2%) on SImax when using ≥40% of CM. There was a larger effect (mean increase, 19.6%) when ≤20% of CM were used. Bolus time length was significantly shorter (P < 0.001), and area under the SI/Tn curve was significantly smaller (P < 0.01) for the CM protocols followed by a saline chaser injected at 6 mL/s compared with a saline chaser injected at 2 mL/s. CONCLUSION:: With 40% of CM and a fast saline chaser, SImax close to that with undiluted CM can be achieved. An increased saline chaser injection rate has a more pronounced effect on aortic enhancement characteristics at lower CM concentrations than at higher CM concentrations.

Abstract

OBJECTIVE:: To evaluate the effect of the contrast medium (CM) concentration and the saline chaser volume and injection rate on first-pass aortic enhancement characteristics in contrast-enhanced magnetic resonance angiography using a physiologic flow phantom. MATERIALS AND METHODS:: Imaging was performed on a 3.0-T magnetic resonance system (MAGNETOM Trio, Siemens Healthcare Solutions, Inc, Erlangen, Germany) using a 2-dimensional fast low angle shot T1-weighted sequence (repetition time, 500 milliseconds; echo time, 1.23 milliseconds; flip angle, 8 degrees; 1 frame/s × 60 seconds). The following CM concentrations injected at 2 mL/s were used with 3 different contrast agents (gadolinium [Gd]-BOPTA, Gd-HP-DO3A, Gd-DTPA): 20 mL of undiluted CM (100%) and 80%, 40%, 20%, 10%, 5%, and 2.5% of the full amount, all diluted in saline to a volume of 20 mL to ensure equal bolus volume. The CM was followed by saline chasers of 20 to 60 mL injected at 2 mL/s and 6 mL/s. Aortic signal intensity (SI) was measured, and normalized SI versus time (SI/Tn) curves were generated. The maximal SI (SImax), bolus length, and areas under the SI/Tn curve were calculated. RESULTS:: Decreasing the CM concentration from 100% to 40% resulted in a decrease of SImax to 86.1% (mean). Further decreasing the CM concentration to 2.5% decreased SImax to 5.1% (mean). Altering the saline chaser volume had no significant effect on SImax. Increasing the saline chaser injection rate had little effect (mean increase, 2.2%) on SImax when using ≥40% of CM. There was a larger effect (mean increase, 19.6%) when ≤20% of CM were used. Bolus time length was significantly shorter (P < 0.001), and area under the SI/Tn curve was significantly smaller (P < 0.01) for the CM protocols followed by a saline chaser injected at 6 mL/s compared with a saline chaser injected at 2 mL/s. CONCLUSION:: With 40% of CM and a fast saline chaser, SImax close to that with undiluted CM can be achieved. An increased saline chaser injection rate has a more pronounced effect on aortic enhancement characteristics at lower CM concentrations than at higher CM concentrations.

Statistics

Citations

4 citations in Web of Science®
4 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:20 Dec 2011 12:51
Last Modified:07 Dec 2017 10:32
Publisher:Lippincott Wiliams & Wilkins
ISSN:0020-9996
Publisher DOI:https://doi.org/10.1097/RLI.0b013e3182300603
PubMed ID:21934516

Download

Full text not available from this repository.
View at publisher