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Frequency and clinicopathologic correlates of KRAS amplification in non-small cell lung carcinoma


Wagner, P L; Stiedl, A C; Wilbertz, T; Petersen, K; Scheble, V; Menon, R; Reischl, M; Mikut, R; Rubin, M A; Fend, F; Moch, H; Soltermann, A; Weder, W; Altorki, N K; Perner, S (2011). Frequency and clinicopathologic correlates of KRAS amplification in non-small cell lung carcinoma. Lung Cancer, 74(1):118-123.

Abstract

KRAS amplification is a common molecular alteration in NSCLC, characterizing ∼15% of tumors. This alteration is associated with indicators of local aggressiveness, and may act synergistically with KRAS mutations to promote tumor progression.

Abstract

KRAS amplification is a common molecular alteration in NSCLC, characterizing ∼15% of tumors. This alteration is associated with indicators of local aggressiveness, and may act synergistically with KRAS mutations to promote tumor progression.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Thoracic Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:04 Jan 2012 10:25
Last Modified:05 Apr 2016 15:15
Publisher:Elsevier
ISSN:0169-5002
Publisher DOI:https://doi.org/10.1016/j.lungcan.2011.01.029
PubMed ID:21477882

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