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Electrochemically stimulated release from liposomes embedded in a polyelectrolyte multilayer


Graf, N; Albertini, F; Petit, T; Reimhult, E; Vörös, J; Zambelli, T (2011). Electrochemically stimulated release from liposomes embedded in a polyelectrolyte multilayer. Advanced Functional Materials, 21(9):1666-1672.

Abstract

Triggered release of an entrapped dye from vesicles embedded in a polyelectrolyte multilayer (PEM), as a consequence of the electrochemically induced local pH change in the vicinity of the electrode, is reported. The PEM was deposited on an indium tin oxide (ITO) electrode wherein lipid vesicles filled with a fluorescent dye were embedded. The use of vesicles with a strong negative charge and the polyelectrolyte species of the PEM matrix with a polycation as topmost layer enabled the generation of a stable layer of liposomes in the PEM.

Abstract

Triggered release of an entrapped dye from vesicles embedded in a polyelectrolyte multilayer (PEM), as a consequence of the electrochemically induced local pH change in the vicinity of the electrode, is reported. The PEM was deposited on an indium tin oxide (ITO) electrode wherein lipid vesicles filled with a fluorescent dye were embedded. The use of vesicles with a strong negative charge and the polyelectrolyte species of the PEM matrix with a polycation as topmost layer enabled the generation of a stable layer of liposomes in the PEM.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Uncontrolled Keywords: polyelectrolyte multilayers; liposomes; electrochemistry; controlled release; pH-sensitive materials
Language:English
Date:2011
Deposited On:04 Jan 2012 14:10
Last Modified:05 Apr 2016 15:17
Publisher:Wiley-Blackwell
ISSN:1616-301X
Publisher DOI:https://doi.org/10.1002/adfm.201002283

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