Header

UZH-Logo

Maintenance Infos

Assembly and breakdown of microtubules within the midbody


Tamir, A; Elad, N; Medalia, O (2011). Assembly and breakdown of microtubules within the midbody. Communicative & Integrative Biology, 4(5):552-553.

Abstract

In animal cells, cell division concludes with the separation of two daughter cells during a process called cytokinesis. Abscission, the termination of cytokinesis, is performed through formation of the midbody, a vis-á-vis microtubule (MT)-rich structure bridging the daughter cells. Disassembly of the midbody is the final stage of daughter cell separation and occurs in parallel to membrane fusion in this area. To shed light on this process and to better understand MT organization within the dense area of the midbody structure, an integrative fluorescence microscopy and cryo-electron tomography (cryo-ET) approach was taken.1 These efforts led to a resolving of MT architecture at single-fiber resolution, resulting in a refined model of abscission.

Abstract

In animal cells, cell division concludes with the separation of two daughter cells during a process called cytokinesis. Abscission, the termination of cytokinesis, is performed through formation of the midbody, a vis-á-vis microtubule (MT)-rich structure bridging the daughter cells. Disassembly of the midbody is the final stage of daughter cell separation and occurs in parallel to membrane fusion in this area. To shed light on this process and to better understand MT organization within the dense area of the midbody structure, an integrative fluorescence microscopy and cryo-electron tomography (cryo-ET) approach was taken.1 These efforts led to a resolving of MT architecture at single-fiber resolution, resulting in a refined model of abscission.

Statistics

Altmetrics

Downloads

67 downloads since deposited on 13 Jan 2012
17 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2011
Deposited On:13 Jan 2012 10:22
Last Modified:07 Dec 2017 11:07
Publisher:Landes Bioscience
ISSN:1942-0889
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.4161/cib.4.5.16050
PubMed ID:22046459

Download

Download PDF  'Assembly and breakdown of microtubules within the midbody'.
Preview
Content: Published Version
Language: English
Filetype: PDF
Size: 163kB
View at publisher