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Importance of toll-like receptor 9 in host defense against M1T1 Group A Streptococcus infections


Zinkernagel, A S; Hruz, P; Uchiyama, S; von Köckritz-Blickwede, M; Schuepbach, R A; Hayashi, T; Carson, D A; Nizet, V (2012). Importance of toll-like receptor 9 in host defense against M1T1 Group A Streptococcus infections. Journal of Innate Immunity, 4(2):213-218.

Abstract

Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models.

Abstract

Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
04 Faculty of Medicine > University Hospital Zurich > Institute of Intensive Care Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2012
Deposited On:21 Jan 2012 10:37
Last Modified:07 Dec 2017 11:25
Publisher:Karger
ISSN:1662-811X
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1159/000329550
PubMed ID:21860217

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